Science & Research
The endocannabinoid system, genetics, and laboratory science.
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Articles
Cannabinoid Receptors CB1 and CB2: Distribution, Signaling, and Drug Targets
Cannabinoid receptors CB1 and CB2 shape intoxication, pain, immunity, and drug response through tissue distribution, signaling bias, and receptor state.
Cannabis Pharmacokinetics: Absorption, Distribution, Metabolism, and Excretion
Cannabis pharmacokinetics varies by route, dose, and formulation. Learn how absorption, metabolism, blood levels, and urine tests differ.
Cannabis Trichomes: Types, Anatomy, Maturity Guide
Cannabis trichomes explained: types, anatomy, biosynthesis, maturity stages, sinsemilla resin, stress effects, microscopy, and potency myths.
Endocannabinoid System (ECS): How Cannabis Works
Endocannabinoid system (ECS) guide covering CB1, CB2, anandamide, 2-AG, FAAH, MAGL, retrograde signalling, homeostasis, THC, CBD, and history.
Entourage Effect in Cannabis: What Evidence Shows
Entourage effect in cannabis: trace the 1998 term, THC-CBD evidence, terpene claims, full-spectrum vs isolate debate, and what studies really support.
Non-CB1/CB2 Molecular Targets of Cannabinoids: TRP Channels, PPARs, GPRs, Serotonin, and NaV Channels
Non-CB1/CB2 molecular targets of cannabinoids include TRP channels, PPARs, GPR55, 5-HT1A, and NaV channels linked to pain, inflammation, and anxiety.